Dérvo Hydration Créma
The Science of Hydration

Ancient Wisdom,
From Field To Formula

8 hero ingredients rooted in 4,000 years of Mediterranean botanical tradition, validated by peer-reviewed clinical research.

I
Red Algae
Red
Algae
φῦκος — phykosBarrier + Longevity
II
Hyaluronic Acid
Hyaluronic
Acid
ὕδωρ — hydorMulti-Depth Hydration
III
Bio Guava
Bio-Optimized
Guava
Bioptimized™ polyphenolsAntioxidant + Anti-Aging
IV
Prebiotic Complex
Prebiotic
Complex
πρό βίος — pro biosMicrobiome + Barrier
V
Ferulic Acid
Ferulic
Acid
Ferula communisProtection + Renewal
VI
Sea Water
Sea
Water
θάλασσα — thalassaMineral + Barrier
VII
Greek Honey
Greek
Honey
Μέλισσα — MelissaHeritage + Healing
VIII
Mountain Tea
Mountain
Tea
σίδηρος — siderosAnti-Aging + Defense
97%
Natural Origin
4,000+
Years of Tradition
42+
Clinical Studies
8 Hero Ingredients

Terraced-Layer Hydration From Each Ingredient,

Each ingredient plays a role—so skin feels cushioned with moisture, supported against stressors, and visibly more refined over time.

Red algae
01
Barrier + Longevity
φῦκος — phykos
Red Algae
Kappaphycus Alvarezii Extract
The ancient Greek word for red algae — phykos — became the Latin word for cosmetics. TELOSOMYL® technology reduces telomere shortening by 65%, improves dermal matrix density by 30.2%, and reduces perceived age by 3 years in just 42 days.
−65%
Telomere shortening
−3 yrs
Perceived age
Water
02
Multi-Depth Hydration
ὕδωρ — hydor (water)
4-Form Hyaluronic Acid
Sodium Hyaluronate · Acetylated · Crosspolymer-2 · Hydrolyzed
Not one HA — four, engineered across molecular weights. A 2024 JCAD study confirmed multi-weight HA is statistically superior to single-weight by Week 2. Four layers work from surface to 100µm deep, holding 1,000× their weight in water.
4 layers
Molecular weights
1,000×
Water retention
Guava
03
Antioxidant + Anti-Aging
Bioptimized™ polyphenols
Bio-Optimized Guava
Psidium Guajava Leaf Extract
Guava delivers 4× the vitamin C of oranges with radical-scavenging power matching pure ascorbic acid. It inhibits tyrosinase, collagenase, elastase, and hyaluronidase — protecting all three dermal matrix components while reducing TNF-α by 51.86%.
Vitamin C vs oranges
−51.9%
TNF-α reduction
Botanical
04
Microbiome + Barrier
πρό βίος — pro bios (for life)
Prebiotic Complex
Inulin + Saccharomyces Lysate Extract
A 2023 multi-omic study showed 6 weeks of prebiotic use increased hydration, reduced pathogens, and enriched fatty acid metabolism. Saccharomyces Lysate boosts oxygen uptake by 750% and increases cell turnover 25%.
+750%
Oxygen uptake
+25%
Cell turnover
Golden field
05
Protection + Renewal
Ferula communis — Prometheus' fire
Ferulic Acid + Thymulen® 4
Ferulic Acid · Acetyl Tetrapeptide-2
Named after the giant fennel in whose stalk Prometheus stole fire. Duke University proved 0.5% ferulic acid doubles photoprotection from 4× to 8×. Paired with Thymulen® 4 — boosting keratinocyte density 51% and immune signaling 450%.
Photoprotection
+450%
GM-CSF activation
Sea
06
Mineral + Barrier
θάλασσα — thalassa (the sea)
Mediterranean Sea Water
Maris Aqua
Hippocrates prescribed seawater baths. Mediterranean sea water at ~38 g/L salinity delivers magnesium, calcium, potassium, zinc, iron, copper, and selenium. Part of the validated GELYMA SEA MOIST COMPLEX®.
38 g/L
Mineral salinity
7+
Essential minerals
Honey
07
Heritage + Healing
Μέλισσα — Melissa (bee / nymph)
Greek Honey
Mel / Honey Extract
A 2022 study proved Greek thyme honey outperforms Manuka — superior antimicrobial activity against MRSA at 12% concentration. A 2024 meta-analysis of 906 patients found honey accelerated healing by 17 days. 180+ bioactive compounds.
Beats Manuka
Antimicrobial power
180+
Bioactive compounds
Mountain
08
Anti-Aging + Defense
σίδηρος — sideros (iron)
Greek Mountain Tea
Sideritis Syriaca Extract
Warriors healed iron-weapon wounds with it on the battlefield. Sato et al. 2022 found it inhibits collagenase, blocks AGE formation, and suppresses UVB-induced MMP-1 — concluding it can "delay or reverse skin aging."
3-way
Aging defense
17
Endemic Greek species
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Formula Intelligence

Every Ingredient Amplifies the Others

This isn't a list of ingredients — it's a self-reinforcing system. Prebiotics optimize the microbiome, maintaining pH for HA stability. HA hydrates the skin, creating an optimal environment for beneficial bacteria. Saccharomyces lysate stimulates endogenous HA. Red algae film prevents moisture loss. Guava inhibits hyaluronidase. Mountain tea protects collagen from MMPs. Ferulic acid shields everything from oxidative damage. Honey seals the system in a hygroscopic, antimicrobial film.

Hydration Architecture
Three Hydration Systems
4-form HA complex for multi-depth moisture · Prebiotics for biological environment · Red algae + sea water + glycerin forming the SEA MOIST COMPLEX®
Defense Network
Three Antioxidant Pathways
Ferulic acid triad for 8× photoprotection · Bio-optimized guava blocking NFkB senescence · Acetyl Tetrapeptide-2 activating thymopoietin renewal
Provenance
Two Greek Heritage Anchors
Thyme honey with 4,000 years of tradition and proven superiority over Manuka · Sideritis syriaca that modern science says can "delay or reverse skin aging"

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